Metformin500 mg: White coloured, film coated, round, biconvex tablets embossed on one face with '850' Metformin 1000mg: White to off white, oval shaped, biconvex, film coated tablets debossed with '10' and '00' on either side of deep notch on one side and breakline on other side. 4 CLINICAL PARTICULARS 4.1 Therapeutic Indications Metformindecreases glucose production from the liver and decreases absorption of glucose from the intestine after taking food while improving the sensitivity of the body organs and muscles towards insulin. This helps improve the uptake of glucose from the blood. It also helps your body to respond better to the insulin it makes naturally. Metforminhydrochloride tablets USP contain 500 mg, 850 mg, or 1000 mg of metformin hydrochloride. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, hypromellose, magnesium stearate, polyethylene glycol, povidone and titanium dioxide. Metformin is an antihyperglycemic agent which improves glucose MetforminHydrochloride Extended release Tablets (Amneal) package insert. Glasgow, KY 42141. Dosing and Dose Equivalence of Metformin Initial dose Titration Maximum dose Metformin (Glucophage) IR Tab 500 mg BID 500 mg Qweek 2550mg/day in 2 or 3 doses Metformin (Glucophage) XR Tab 850 mg QDay 850 mg Qweek 2550mg/day in 2 or 3 doses Metformin Metforminis the most common drug used and is the first-line agent in type 2 diabetes management. It is also considered one of the safest pharmacological agents for the treatment of the disease. However, gastrointestinal side effects are common, occurring in up to 75% of those who take metformin ( 2 ). 5lLcw.

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